Air pollution, both indoor and outdoor, poses significant health risks, especially for young children in daycare centers. Children playing indoors and outdoor playgrounds also release particulate matter, including submicron nanoparticles. This study compares nanoparticle concentrations in indoor daycare environments and outdoor air using a Nanoscan nanoparticle monitor. Geometric mean (GM) and geometric standard deviation (GSD) were used to better characterize exposure patterns. Measurements taken at 12:30 PM in the indoor lobby area of a daycare center at GSU showed a GM of 1.22E+03 and a GSD of 1.38 total nanoparticles per cubic centimeter of air, while outdoor measurements from the children’s playground at 4:50 PM recorded a GM of 1.76E+03 and a GSD of 1.21 total nanoparticles per cubic centimeter of air, both taken on the same day. Results indicate that nanoparticle concentrations are consistently higher outdoors than indoors, with greater variability in outdoor air quality due to childcare activities.