Breast cancer is the most common cancer in women, accounting for 1 in 8 female cancers, necessitating the search for novel therapeutic agents. Pyridazines derivatives exhibit anti-cancer, anti-diabetic, and anti-fungal properties towards biological and agricultural applications. This study focuses on the synthesis and characterization of these compounds, followed by an investigation of their biological properties relevant to breast cancer treatment. Previous studies show that these derivatives exhibit promising interactions with key cellular targets involved in cancer progression. The multi-component synthesis of pyridazines derivatives can be achieved using ionic liquids, which provides a grenner alternative to traditional solvents in organic synthesis.