Ferritin and transferrin are the two proteins that control iron metabolism. If all their binding sites are occupied, excess iron circulates in the bloodstream. This iron overloaded state leads to the production of reactive oxygen species (ROS) and oxidative stress. Free iron can be removed from the body by iron chelation therapy, which involves adding a molecule that chelates iron. Today, there are several iron chelators on the market but many are expensive and painful to administer. Our laboratory seeks new iron chelators. Curcumin, the active ingredient in turmeric, has numerous biochemical properties serving as an antioxidant, anti-microbial, anti-inflammatory, and metal chelation compound. The purpose of this research is to determine if curcumin is a viable candidate for iron chelation therapy. Results will be presented to demonstrate curcumin’s ability to remove iron from ferritin and transferrin, along with its ability to remove free iron within a solution.
