Celiac disease (CD) and non-celiac gluten sensitivity (NCGS) are two disease states related to the consumption of gluten. This study aims to compare the existing literature on each disease’s pathophysiology, incidence, diagnosis, current treatment, and treatment outcomes. The search engines Galileo, Pubmed, and the National Library of Medicine were used to gather data for this study. CD is characterized by chronic inflammation of the small intestinal mucosa and several other gastrointestinal manifestations. (Rodrigo, 2006). Its incidence is increasing worldwide, with the highest rates in Europe and North America (Gujral et al, 2012). Meanwhile, NCGS is poorly defined and difficult to diagnose due to a lack of serological and histological biomarkers (Barbaro et al, 2020). Its incidence is estimated between 0.5-13% in the general population (Barbaro et al, 2015). The only known treatment for both diseases is a lifelong avoidance of gluten (Raymond et al, 2006).
