Three-dimensional (3D) printing technology has become integral to modern innovation. Notably, hazardous substances linked to plastics and resins used in 3D printing have been identified as carcinogens and occupational health hazards in manufacturing. This study aims to assess the particulate matter (PM) and volatile organic compounds (VOCs) emitted during 3D printing processes. The physical characteristics of emitted particles, including particle number, size distribution, morphology, and chemical composition, will be analyzed using a combination of advanced instrumentation. Measurements will be conducted using OPC-N3 sensors (OPC-N3, Alphasense Ltd.), a TSI SidePak personal aerosol monitor (Model AM510, TSI Inc.), a TSI NanoScan scanning mobility particle sizer (Model 3910, TSI Inc.), and a DX4040 Fourier-transform infrared (FTIR) gas analyzer (Model DX4040, Gasmet Technologies Oy., Finland). The preliminary data suggested although particle mass concentrations and VOC concentrations during the printing process do not exceed the exposure threshold values, nanoparticle exposures still warrant caution.